Dear Friends and Family,

This fall we've been cheering on the #1 football team in the country, but there's something else to cheer about - THE CYSTIC FIBROSIS BOWL FOR BREATH. On Sunday, November 5 the Pace family will participate in their 28th fundraiser for the Cystic Fibrosis Foundation. Over the years you have helped us raise over $70,000 and we won't stop until a cure is found.

FAMILY UPDATE: Brent was diagnosed at age three and a half. He learned to sit still through hand percussion that was done on the special table Jim made. He can remember it was also where spelling words and math facts were learned. Now, a ThAirapy vest (treatment machine) does the percussion. Brent will turn 32 in April and as mentioned two years ago has his treatment machine in his car (now a Mini Cooper). His postural drainage is done to and from work. Brent goes to the CF Adult center in Charleston, South Carolina. His health this year has been good, just a tune up with a round of IV antibiotics. His environmental engineering job, band jobs all over the country, and soccer keep him busy. Lynnette is a great southern hostess and guests are always welcome.

Derik was diagnosed at 6 months and can't remember life without aerosols and postural drainage. Our house even had a room called the Treatment Room! The therapy vest came along when he began culinary school. He has been cared for all these years at the CF Center at Children's Hospital. In March 2006 Derik was allowed to drive again after being seizure free for 6 months. (no CF connections and still no explanation as to the cause). Despite fluctuating weight, a round of IV antibiotics allowed him to end the year on a positive note. Cooking remains his passion and he continues with Aramark at JP Morgan Chase. Our number 1 bowler is Derik's wife, Misty.

This year we will all be missing one of our biggest supporters over all of our years of bowling. Linda's dad, Harry Whitehouse, passed away in January. He so much believed in supporting research for CF that he asked for donations in his memory were to be made to the CF Foundation . Dad, you will be there in spirit. We dedicate our fund raising efforts to him.

We fund raise for CF. Not only for our boys, but for:

• All the newly diagnosed families that are struggling to make sense of things
• Those who cope with hospital stays
• All the parents who make sure that medicine is picked up and treatments completed
• CF Kids who just want to live life like everyone else
• The teenagers who want to know "Why me?"
• The adults with CF that cope with insurance, jobs, and family responsibilities
• The loving hands at the CF Centers that care for the patients
• Those who have lost children to this disease

New Research:

• SURFING IS HEALTHY! Surfers with CF in Australia told their doctors their airways felt clearer after exposure to salt spray. Further study has confirmed that inhaling a mist of saline solution can reduce pulmonary "flare-ups". CF patients may want to discuss this "low-tech" treatment with their doctors!
• The Cystic Fibrosis Foundation has about 33 drugs in their "CF Drug Development Pipeline" spanning the areas of Gene Therapy, Protein Assist/Repair, Restore Salt Transport, Mucus Treatment, Anti-inflammatory, Anti-infective, Lung Transplant drugs, and Nutritional Supplements. These don't include the many drugs and treatment possibilities already in use!
• A new technology called PREDICT (created by a company called Predix - go figure...) is now being used to model the CFTR protein (the defective protein in the gene causing CF) and to screen for drugs which might be used to treat the symptoms of CF.
• If you wonder why there are so many different treatment possibilities for CF, here's part of the answer: There are over 100 variations or mutations in this disease we call "CF". Further, even though both Brent and Derik have one of the more common variants of CF, they are affected by the disease differently and have different treatment regimens. Each case of CF is treated individually and changes over time as the disease progresses and as new treatment options are made available. And these treatments ARE WORKING! In the last four years, more than five years have been added to the median survival age of CF patients. In just the past year, the median age has risen from 35.1 years to 36.8 years!
• The CF Foundation has recommended all states perform newborn testing for CF. To date, 40 states require newborn testing for CF. Ohio started requiring this test at the end of August, 2006. The remaining 10 states are in various stages of implementing this test. People with CF who are diagnosed at birth gain more weight and have better nutrition than those who are diagnosed later in life. Better nutrition and weight gain in children with CF has been linked to a slower decline in respiratory function, the primary cause of death in CF. Every year, the future looms brighter!

The Pace family will bowl on November 5, 2006. Your tax-deductible contribution sent to us (payable to The Cystic Fibrosis Foundation) will have a tangible impact on conquering this disease!

To all of YOU who have supported the Cystic Fibrosis Foundation, WE GIVE OUR THANKS! If this is your first contribution to CF, WELCOME TO OUR TEAM! You are ALL our heroes!

Jim, Linda, Brent, Derik, and Misty Pace

PS: More information about cystic fibrosis research is available at the CF Foundation web site at:

• http://www.cff.org